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SARMs and prohormones

Have you already heard of SARMs? It stands for selective androgen receptor modulators. They serve as the perfect alternative to ASs. They represent almost miraculous substances that can help you reach the figure of your dreams. And all of this very easily, quickly and safely. 

What are SARMs?

SARMs, or selective androgen receptor modulators, contain androgens. Androgens are a special type of hormones, which act as ligands (molecule linked to another molecule), which are connected to the cellular androgen receptors. These receptors are integrated in complex signal networks, which ultimately results in greater expression of the gene. Thanks to this binding to androgen receptors both ASs and prohormones cause muscle growth. 

SARM is a drug that can either act as a blocking agent or can stimulate hormone receptors under various conditions. In case it is able to block or stimulate the receptor in selective tissue, it is able to mimic the beneficial effects in one type of tissue, while minimizing the side effects of natural or synthetic AS hormones in other tissues.

These compounds are an absolute novelty and are currently in the testing program of several major pharmaceutical companies.

How were the SARMs created?

Steroids in medicine are prescribed for two reasons:

  • hormone replacement therapy,

  • reduction of muscle mass for various reasons (osteoporosis, cancer, trauma, injury).

Problems with ASs or tste replacement therapy result from their negative side effects on the health of the patient. If the SARMs are able to stimulate receptors selectively, they can mimic the beneficial effects of androgens activation in the tissue (in this case bones and muscles) of muscles while minimizing the risk of negative side effects.

It is this specificity which makes the modulators capable of selective activity. They increase muscle mass while reducing or eliminating undesirable side effects. SARMs are therefore a suitable alternative to previously prescribed AS.

Benefits of the SARMs use compared to the application of ASs:

  • oral form of use (no need of injecting)

  • similar effects as when taking tste (increased muscle mass, strength, increased libido, reduction of blood fat)

  • no conversion to DHT (dihydrotste)

  • no conversion to estrogen

  • no liver toxicity

  • undetectable in drug tests

The most popular SARMs:

LGD-4033 – powerful, non-ASal, designed especially for bodybuilders who want to increase muscle mass and reduce the amount of subcutaneous fat.

Ostarine (MK-2866) – selective for anab. activity in certain ARS, perfect for maintaining and increasing lean muscle mass and recomping.

S4 (Andarine) – selective for bone tissue, focusing on the treatment of osteoporosis. Doesn't produce side effects on prostate growth.

GW 501516 (Cardarine) – burns fat and prevents muscle loss. It will help you get your training to a new level. Known as the king of endurance supplements. It is not a SARM but rather a PPAR receptor agonist.

MK 677 (Nutrobal) – increases the secretion of gh and growth factor IGF-1.

RAD140 – higher anab. effect than AS. Large muscle gains in a shorter time.

SR9009 – binds to Rev-erbα (one of the natural molecules of the body), which affects the metabolism of lipids and glucose in the liver.

YK11 – considered the strongest SARM, much more effective than AS alone. It affects the levels of myostatin. 

SARMs vs. prohormones

Prohormones were on the market much earlier than the SARM products. We can say that SARMs are a modern version of ASs. They may be orally administered, minimize the effects of higher levels of tste in the blood, are intended for treatment of various diseases, for which AS were or still are used.

According to the study conducted by the World Anti-Doping Agency (WADA), about a tenth of the world's athletic population uses SARMs (especially Ostarine) in order to enhance their performance while they don't need to worry about their health.

Use of the SARM products is justified in combination with prohormones or in a transfer period between AS cycles, when they help keep maximum of the acquired muscle mass and strength, and the body recovers without problems.

Their mutual combination with prohormones can only help so that you can record massive growth of muscle mass and strength. In addition, the combination of SARM compounds and prohormones is suitable to pre-competitive diet and to the recomp period (simultaneous reduction of fat and gaining of muscle mass). 

  Lean muscle mass and strength growth Massive mass growth Recomp Pre-competitive preparation
LGD-4033 x   x x
Ostarine (MK-2866) x x x x
S4 (Andarine) x   x x
GW 501516 (Cardarine) x     x